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| Mechanism of Toxin Damaging Brain Collaterals in Rats with Hippocampus Ischemia of Acute Multi-infarction |
| Hits 1645 Download times 2168 Received:April 21, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.04.25 |
| Key Words
acute multiple cerebral infarction model;energy metabolism;free radical;toxin damaging brain collaterals |
| Author Name | Affiliation | | ZHANG Jin | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | ZHANG Yun-ling | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | LOU Jin-li | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 张綦慧 | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 郑宏 | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 闫妍 | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 黄启福 | 北京中医药大学基础医学院, 北京, 100029 |
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| Abstract
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| [Objective] To explore the theory of toxin damaging brain collaterals based on the cascade reaction in acute brain ischemia,including disturbance of energy metabolism,acidosis and free radical injury and the regulative effect of traditional Chinese medicine.[Methods] Acute multiple cerebral infarction was induced by injection of homologous microemboli.72 hours after ischemia the rats were killed and the brain samples with ischemia were obtained.The pathologic changes of the CA1 region of hippocampus were examined after HE staining light microscopically.The activity of Na+-K+-ATPase,lactate dehydrogenase(LDH),malondialdehyde(MDA)and superoxide dismutase(SOD)in the hippocampus tissue was measured with colorimetric determination.[Results] The morphologic changes of ischemia in CA1 region of hippocampus in rats with acute multiple infarction were obvious.The activity of the Na+-K+-ATPase,LDH and SOD of hippocampus tissue in model group was obviously decreased(P<0.01).However,in the TCM group it was obviously higher than that in model group(P<0.01).The MDA content of model group markedly increased in hippocampus tissue(P<0.05),but in the TCM group it obviously decrease when compared with model group(P<0.01).[Conclusions] In the course of acute brain ischemia injury the important cascade reaction,including disturbance of energy metabolism,acidosis and free radical injury has provided the pathologic and physiologic foundation for the mechanism study of toxin damaging brain collaterals. |
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