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| Effect of Yinshendaluoyin on MCP-1 of Mice with Experimental Autoimmune Encephalomyelitis |
| Hits 1549 Download times 1894 Received:May 06, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.05.17 |
| Key Words
autoimmune encephalomyelitis;multiple sclerosis;Yishendaluoyin;MCP-1 |
| Author Name | Affiliation | | SHANG Xiao-ling | | | GAO Ying | | | Yin Ling | | | 张金涛 | | | 张笑明 | |
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| Abstract
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| [Objective] To investigate the effect of Yishendaluo(tonifying kidney and dredging collateral) decoction on MCP-1,the chemotactic factor of central nervous system,in mice with PLP139-151-induced experimental autoimmune encephalomyelitis and explore the mechanism of Yishendaluo decoction on the inflammatory demyelinating diseases in the nervous system.[Methods] Female mice were evenly randomized into normal control,model,hormone and traditional Chinese medicine groups. The contents of MCP-1 protein and MCP-1 mRNA were detected by immunohistochemistry and in situ hybridization of digoxin-labeled oligonucleotide probe.[Results] The contents of MCP-1 protein and MCP-1 mRNA in model,hormone and traditional Chinese medicine groups were all significantly higher than those in normal control group (P<0.01). Compared with model group,the augmentation in contents of MCP-1 protein and MCP-1 mRNA in both hormone group and traditional Chinese medicine group was significantly diminished (P<0.01). In contrast to hormone group,the contents of MCP-1 protein and MCP-1 mRNA in traditional Chinese medicine group were decreased (P<0.05).[Conclusions] The results of the present study indicate that Yishendaluo decoction can protect the mouse from the injury of experimental utpommune encephalomyelitis by attenuating the content of MCP-1,inhibiting the chemotaxis of monocytes and lessening the local inflammation. |
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