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| Protective Effect of Preconditioning with Gold Theragran Salvia Miltiorrhiza Prescription on Myocardium in Rats with Ischemia and Reperfusion |
| Hits 1537 Download times 1611 Received:February 08, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.05.18 |
| Key Words
myocardial injury of ischemia and reperfusion injury;oxygen free radical;myocardium enzyme;experimental study |
| Author Name | Affiliation | | WANG Yi | | | WANG Shao-xia | | | REN Ming | | | 张萌 | | | 刘洋 | | | 姜志浩 | | | 高秀梅 | | | 张伯礼 | |
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| Abstract
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| [Objective] To observe the effect of Gold Theragran Salvia Miltiorrhiza Prescription(GTSMP) on the myocardial infarction volume and the activity of LDH,CK,CK-MB,SOD,MDA in rats with of ischemia and reperfusion(I/R) injury.[Methods] The rats were randomly divided into seven groups: sham operation group,I/R group,high dosage of GTSMP group,middle dosage of GTSMP group,low dosage of GTSMP group,control group of compound Salvia Miltiorrhiza dripping pills and Dinitrosorbide. The myocardial I/R injury model was induced by ligating anterior descending coronary artery of rats for 30 minutes and opening for120 mintues. After preconditioning with GTSMP,those parameters described above were observed and the change of myocardium ultrastructure was examined by electron microscope.[Results] The infarction extent of high and middle dosage of GTSMP group was obviously lessened. The percentage of the weight of the infracted area to the weight of whole heart and left ventricle was markedly decreased when compared with that of I/R group(P<0.01-0.001). The middle dosage of GTSMP group had the best effect. GTSMP may enhance the decreased serum SOD content in I/R group(P<0.01) and decrease MDA content in different extent and leakage of myocardium creatine kinase(P<0.01). GTSMP may decrease myocardium injury demonstrated from electron microscope examination.[Conclusions] GTSMP may lessen the myocardium infarction volume in rats with I/R,inhibit the releasing of CK,CK-MB,LDH and the production of MDA,increase the activity of SOD after I/R. It is showed that GTSMP has protective effect against the myocardial injury of I/R,decrease the release of myocardial enzyme and oxygen free radical injyry. It may be one of the important mechanisms for protecting myocardium. |
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