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| Decreasing Oxygen Radical Damage by Taking Astragalus and Arsenolite together in Rats |
| Hits 1325 Download times 1496 Received:May 06, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.05.19 |
| Key Words
astragalus;arsenolite;oxidative damage;free radical;toxic action |
| Author Name | Affiliation | | YI Zhen-nan | | | LIANG Biao | | | SONG Ze-qing | | | 黄仁清 | |
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| Abstract
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| [Objective] To investigate the possible mechanisms of oral administration of astragalus in decreasing liver toxic action and the oxidative damage in rats injured by arsenolite.[Methods] Fifty SD rats were randomly divided into five groups: group A (normal control group),group B (arsenolite control group),group C(arsenolite plus low dose of astragalus group),group D (arsenolite plus middle dose of astragalus group),group E (arsenolite plus high dose of astragalus group). All the determined medicines were given once a day. 12 weeks after feeding the animals were sacrificed. The level of serum malondialdehyde (MDA),superoxide dismutase (SOD),glutathione peroxidase (GSH-PX),alanine aminotrans-ferase(ALT) were detected. The samples of liver were harvested to observe the pathological change with light microscopy.[Results] Compared with group B,the contents of MDA decreased,the activity of T-SOD and GSH-PX function improved markedly (P<0.05 or P<0.01) in group C,D and E,the difference was significant statistically.[Conclusions] Oral administration of astragalus membranccus and arsenolite together may decrease the oxygen radical damage and the liver injury induced by arsenolite in rats obviously. |
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