Key Words
Yunpi decoction;aromatic drugs with effect of dissipating dampness;isolated stomach of rats;contractive motility
Author Name
Affiliation
ZHANG Ya-rui
LIU Rong
TANG Fang
Abstract
[Objective] To investigate the effect of Yunpi(activating the spleen) decoction on the gastric dynamics and explore the mechanism primarily.[Methods] The decreasing of the gastric dynamics was induced in rats by ischemia and reperfusion of the lower extremity. Taking atropine and propranolol as the control medicine the effect of Yunpi decoction on the tension of the isolated muscular strip of gastric corpus and the contractive amplitude were investigated.[Results] Yunpi decoction with a increasing concentrations(15,30,60 g/L) could increase the construction amplitude of the muscular strip of the gastric corpus in a dose-dependent manner and without significant effect on the tension. It didn’t exhibit effective antagonism against the relaxation of the muscular strip induced by the antagonist of M-receptor. However,it did show marked antagonism against propranolol (the antagonist of β-receptor).[Conclusions] The decoction of Yunpi decoction may dose-dependently raise the movement amplitude of muscle strip of gastric corpus of rats with disturbance of gastric dynamics and can significantly inhibit the relaxation induced by the antagonist of β-receptor.
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