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| Experimental Study on Time-effect Relationship in Treating Cerebral Hemorrhage with Acupuncture in Rats |
| Hits 1474 Download times 1719 Received:August 12, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.06.11 |
| Key Words
cerebral hemorrhage;acupuncture treatment;Ca2+;SOD;MDA;EAA |
| Author Name | Affiliation | | WANG Zhen-yu1 | Yingkou Hospital of TCM, Yingkou, China | | LI Lin1 | Yingkou Hospital of TCM, Yingkou, China | | LI Ping | Tianjin Nankai Hospital, Tianjin 300100, China |
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| Abstract
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| [Objective] To explore the time-effect relationship and the main mechanism of acupuncture in treating cerebral hemorrhage in rats.[Methods] A model of cerebral hemorrhages in rats was established by using two steps of injection of autologous blood to observe the changes of intracellular free calcium(Ca2+),contents of SOD,MDA in brain tissue and the content of EAA in hippocampus tissue in different time after acupuncture respectively.[Results] We found that acupuncture could decrease the concentration of(Ca2+)in injured neural cells,increase the activity of SOD,reduce the production of MDA in brain tissue and inhibit the increasing of the content of EAA in hippocampus tissue.There was a statistic difference(P<0.05).There was a significant difference between the group of 3 hours treatment and the other three groups;and there was no significant difference between the group of 12 hours treatment,24 hours treatment and 48 hours treatment.[Conclusions] The acupuncture treatment possesses some protective effect against cerebral hemorrhage in rats.It can protect brain cells from cerebral hemorrhage in rats and the earlier treatment the better effect. |
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