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| Experimental Study on Mechanism of Detoxification and Removing Blood Stasis Formula II in Preventing and Treating Hepatic Encephalopathy in Rats with AHG |
| Hits 1464 Download times 2017 Received:June 30, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.06.20 |
| Key Words
acute hepatic failure;hepatic encephalopathy;mechanism;the detoxification and removing blood stasis formula II |
| Author Name | Affiliation | | MAO De-wen | Liver disease treating center, No.1, Affiliated Hospital to Guangxi Chinese Medical University, Nanning, 530023, China | | QIU hua | Liver disease treating center, No.1, Affiliated Hospital to Guangxi Chinese Medical University, Nanning, 530023, China | | HUANG Gu-ye | Liver disease treating center, No.1, Affiliated Hospital to Guangxi Chinese Medical University, Nanning, 530023, China | | 胡振斌 | Liver disease treating center, No.1, Affiliated Hospital to Guangxi Chinese Medical University, Nanning, 530023, China | | 刘洁 | Liver disease treating center, No.1, Affiliated Hospital to Guangxi Chinese Medical University, Nanning, 530023, China |
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| Abstract
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| [Objective] To observe the mechanism of detoxification and removing Blood Stasis Formula II in preventing and treating hepatic encephalopathy in rats with acute hepatic failure(AHF).[Methods] Eighty-four rats with acute hepatic failure induced by injecting TAA were divided into seven groups:control group,treatment group,detoxification and removing blood stasis formula II groups of low,middle,high doses.lactulose group and angong niuhuan wan(Bezovr pill for miscarriage prevention)group.The level of serum NH3,BCAA,AAA,the activity of Na+-K+-ATPase,Ca2+-Mg2+-ATPase,SOD and the content of Ca2+ and MDA in cerebral mitochondrion were determined.[Results] The detoxification and removing blood stasis formula II was able to notably reduce the level of NH3,recover the ratio of BCAA/AAA,increase the activity of Ca2+-Mg2+-ATPase,Na+-K+-ATPase and SOD,inhibit the production of MDA and remain Ca2+ homeostasis in encephalic mitochondrion.The effect of high dose group is better than lactulose and the Chinese medicine angong niuhuang pill for miscarriage prevention groups(P<0.05).[Conclusions] The detoxification and removing blood stasis formula II can protect hepatic encephalopathy in rats with acute hepatic failure.Its mechanism might be due to reducing the content of NH3,recovering the ratio of BCAA/AAA,protecting the function of cerebral mitochondrion. |
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