|
| Protective Effects and Mechanism Research of Naoshuning on Brain Hemorrhage Injury in Rats |
| Hits 1332 Download times 1690 Received:June 30, 2006 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2006.06.22 |
| Key Words
brain hemorrhage;Naoshuning;impairment of nervous function;brain edema |
| Author Name | Affiliation | | ZHANG Mei-kui1 | The Nervous Information Center of PLA General Hospital, Beijing 100853, China | | YIN Ling1 | The Nervous Information Center of PLA General Hospital, Beijing 100853, China | | CUI Xu | The Institute of Gerontology of PLA General Hospital, Beijing 100853, China | | 杜侃 | The Nervous Information Center of PLA General Hospital, Beijing 100853, China | | 崔向宁 | The Nervous Information Center of PLA General Hospital, Beijing 100853, China | | 张笑明 | The Nervous Information Center of PLA General Hospital, Beijing 100853, China | | 宋岳涛 | The Nervous Information Center of PLA General Hospital, Beijing 100853, China | | 刘凤荣 | The Nervous Information Center of PLA General Hospital, Beijing 100853, China | | 田淑君 | The Nervous Information Center of PLA General Hospital, Beijing 100853, China | | 李莉 | The Nervous Information Center of PLA General Hospital, Beijing 100853, China | | 韩志涛 | The Institute of Gerontology of PLA General Hospital, Beijing 100853, China |
|
| Abstract
|
| [Objective] To observe the improvement effects and the effect 8mechanism of Naoshuning prescription against the impairment of nervous function and brain edema in rats with acute brain hemorrhage rats.[Methods] Eighty-four rats were randomly divided into false operation group,brain hemorrhage group,lower dosage of Naoshuning group,middle dosage of Naoshuning group,high dosage of Naoshuning group,mannitol group.Brain hemorrhage model in rats was established by using autoblood transfusion method.The nervous function score,the walking ability on wood strips and the water content of brain tissue on the twenty-fourth and forty-eighth hour after brain hemorrhage were determined.[Results] The middle and high dosage group of Naoshuning may obviously improve nervous function impairment and the strip walking ability.The water content of Naoshuning and mannitol group was obviously lower than that of model group.[Conclusions] Naoshuning may obviously improve the impairment nervous function and decrease the brain water content.The effect mechanism may be related to lessening vasogenic brain edema. |
|
|
|
|
|
|
|
