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| Protective Effect of Tangshenqing-1 on Kidney in Rats with Diabetic Nephropathy |
| Hits 2153 Download times 1803 Received:July 11, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.06.25 |
| Key Words
diabetic nephropathy;Tangshenqing-1;experiment |
| Author Name | Affiliation | | DI Fu-sheng | The Third center Hospital, Tianjin 300170, China | | GAO Ying-tang | The Third center Hospital, Tianjin 300170, China | | ZHU Zheng-yan | The Third center Hospital, Tianjin 300170, China | | 丁贤 | The Third center Hospital, Tianjin 300170, China | | 魏素 | The Third center Hospital, Tianjin 300170, China |
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| Abstract
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| [Objective] To investigate the renal protective effect of Tangshenqing-1(treating diabetic nephropathy)in rats with diabetic nephropathy.[Methods] Thirty-six rats with intraperitoneal alloxan induced diabetic nephropathy were randomly divided into three groups with 12 animals in each:normal control(A),diabetic nephropathy without any treatment(B),and diabetic nephropathy treating with Tangshenqing-1(C).After the model was established Tangshenqing-1 was administered.Eight weeks later the 24 h urine and blood samples were collected.Then rats were killed.The kidneys were harvested for microscopic,electro-microscopic,immunohistochemistry and molecular biology examination.[Results] The TGF-b1 gene and protein expression,the creatinine clearance rate and urea protein in the kidney tissue of rats with diabetic nephropathy were significantly higher in group B and groupC than groupA(P<0.01).However,the degree of diabetic glomerular-sclerosis were decreased by treatment of Tangshenqing-1.[Conclusions] Tangshenqing-1 can protect diabetic kidney through deceasing the expression of TGF-b1. |
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