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Protection of bilobalide B on cholinergic system of neurons in cholesterol and apoE4 injured hippocampus
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DOI   10.11656/j.issn.1672-1519.2007.01.27
Key Words   Alzheimer’s Disease(AD);cholesterol;apolipoprotein E4(apoE4);bilobalide B;acetylcholine(Ach)
Author NameAffiliation
DU Yun  
JIANG Xi-juan  
LU Bin  
范英昌  
Abstract
    [Objective] To observe the protective effect of bilobalide B against the injury of cholinergic system of hippocampal neurons induced by combined cholesterol and apoE4.[Methods] Hippocampal nrurons were manipulated by cholesterol and apoE4.The content of acetylcholine,activity of acetylcholinesterase and choline acetyltransferase was examined by microdosage hydroxylamine colorimetry,hydroxylamine colorimetry and radiological chemistry respectively.[Results] Bilobalide B could increase the level of acetylcholine and activity of choline acetyltransferase,while there was no obvious effect on activity of acetylcholinesterase.[Conclusions] The cholinergic system of hippocampal neurons damaged by High concentration cholesterol and apoE4 may be involved in the onset of senile dementia and can induce Alzheimer’s Disease.Bilobalide B has protective effect against the injury of hippocampal neurons.

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