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| Effect of Xinfukang on left ventricular remodeling and function after myocardial infarction in rats |
| Hits 1398 Download times 1745 Received:February 12, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2007.02.23 |
| Key Words
Xinfukang;myocardial infarction;ventricular remodeling;Left ventricular function |
| Author Name | Affiliation | | MA Wen-li | The Department of Pathology of Tianjin University of TCM, Tianjin 300193, China | | GUO Mao-juan | The Department of Pathology of Tianjin University of TCM, Tianjin 300193, China | | ZHAO Xu | The Department of Pathology of Tianjin University of TCM, Tianjin 300193, China | | 徐秀梅 | The Department of Pathology of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To study the impact of Xinfukang on left ventricular remodeling (LVRM) and cardiac function after myocardial infarction (AMI) in rats. [Methods] Myocardial infarction was induced by ligating the descending left coronary artery in male rats. Twenty-four hours later, 48 survived rats with MI were randomly divided into myocardial infarction (MI) control group, sham-operated group, Xinfukang middle dose group and Xinfukang high dose group. After 4 weeks of therapy, the cardiac function was measured. [Results] Compared with sham operated group, all the LVDd, LVDs, IVSd, IVSs, LVPWd and LVPWs, EF, CO, FS of treatment group were statistical different (P<0.05). The collagen fibers of sham operated group were increased and disordered. [Conclusions] Xinfukang can prevent LVRM after MI in rats, improve cardiac function, prohibit collagen fibers hyperplasia. |
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