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| Effect of Qianggudan on bone density and biomechanics in oophorectomized rats with osteoporosis |
| Hits 1632 Download times 1680 Received:November 03, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2007.02.28 |
| Key Words
Qianggudan;oophoectomized rats;osteoporosis;bone density;bone biomechanics;E2 |
| Author Name | Affiliation | | XUAN Ming-shi | Tianjin University of TCM, Tianjin 300192, China | | WANG Ling | 天津中医药大学, 天津, 300193 | | HA Xiao-xian | 天津中医药大学, 天津, 300193 | | 于顺禄 | 天津市骨科医院骨科研究所, 天津, 300211 | | 李彦 | 天津中医药大学, 天津, 300193 | | 王志华 | 天津中医药大学, 天津, 300193 |
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| Abstract
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| [Objective] To observe the effect of Qianggudan(strengthening bone pellet) on bone density and biomechanics in oophorectomized rats with ostepporosis and explore its effect in treating postmenopausal osteoporosis. [Methods] oophorectomized osteoporosis was established with ovariectomy in rats to explore the therapeutic effect for postmenopausal osteoporosis. The rats were randomly divided into five groups, containing 10 animals each: sham operated group, model group, the high, middle and low dosage of Qianggudan group. Four days after ovariectomy the rats were given with normal saline, high, middle and low dose of Qiangudan and diphosphate respectively. Fourteen weeks later all the animal were sacrificed to determine the serum E2, bone density, bone-mine content and bone biomechanics. [Results] The Qianggudan might obviously enhance the serum estrogen-2(E2) level, increase bone density and bone-mine content, obviously enhance the largest load of tibia. [Conclusions] The Qianggudan may prevent and treat postmenopausal osteoporosis by enhancing E2 level, bone density, decreasing bone conversion rate and effectively maintaining the ability of bone biomechanics. |
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