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| Influence of Tongmai Jiangzhi Granula on blood fat and endothelin level after the operation of percutaneous transluminal coronary angioplasty |
| Hits 1829 Download times 2010 Received:February 01, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2007.03.05 |
| Key Words
Tongmai Jiangzhi Granula;percutaneous aorta angioplasty;cholesterin;triglyceride;endothelin |
| Author Name | Affiliation | | ZHAO Ying-qiang | The second Hospital Affiliated Tianjin University of TCM, Tianjin 300150, China | | SUN Lan-jun | The second Hospital Affiliated Tianjin University of TCM, Tianjin 300150, China | | WANG Rui-hua | The second Hospital Affiliated Tianjin University of TCM, Tianjin 300150, China | | 郑偕扣 | The second Hospital Affiliated Tianjin University of TCM, Tianjin 300150, China |
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| Abstract
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| [Objective] To observe the effect of Tongmai(promoting blood circulation) Jiangzhi(lowering hyperlipemia) granula on blood lipid and endothelin level in rats with experimental hyperlipoidemia after operative injury of aorta. [Methods] Sixty wistar rats were randomly divided into six groups: blank group, model group, high lipid group, Tongmai Jiangzhi granula group, Tongxinluo capsule group, probucol control group. Except for the rats of blank group, each rat in the other 5 groups was fed with high fat foodstuff for two weeks. The rat model with percutaneous transluminal coronary angioplasty two weeks later was established. We keep on feeding the rats to medicine three weeks. After administration of medicine for 3 weeks the blood was harvested to observe the effect of Tongmai Jiangzhi granula on blood lipid and endothelin level, and explore the relationship between the level of the blood lipid, endothelin and restenosis. [Results] Comparing to blank group, there was a significant increasing of the level of cholesterin, triglyceride and endothelin in model group(P<0.05). In contrast with model group, however, there was an obvious reducing in the level of cholesterin, triglyceride and endothelin in Tongmai Jiangzhi granula group(P<0.05). [Conclusions] Tongmai Jiangzhi granula may decrease the level of cholesterin, triglyceride and endothelin, and has some interventional effects on the aorta injury induced by percutaneous transluminal coronary angioplasty operation. |
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