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| Effect of acupoint catgut embedding therapy on hippocampal neurons apoptosis and apoptosis-associated genes expression in rats with status epilepticus |
| Hits 1456 Download times 2295 Received:December 23, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2007.03.16 |
| Key Words
Epilepsy;acupoint catgut embedding therapy;apoptosis;gene expression |
| Author Name | Affiliation | | CHEN Guo-rong | Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China | | TANG Chun-zhi | Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China | | XIAO Sheng-hong | Department of Anesthesiology, the Second People’s Hospital of Guangzhou, Guangzhou 510150, China | | 冯淑兰 | Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China | | 徐志伟 | Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China | | 何新芳 | Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China | | 张家维 | Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China |
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| Abstract
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| [Objective] To observe the effects of acupoint catgut embedding therapy hippocampal neurons apoptosis and the expression of associated genes P53 and Bcl-2 in rats with status epilepticus (SE). [Methods] Forty SD rats were randomized into normal group, model group, catgut embedding group, acupuncture group and positive control group. Rat models with SE were established by intraperitoneal injection of bemegride. Forty-eight hours after the establishment of the models, hippocampal neurons apoptosis and the expression of associated genes P53 and Bcl-2 in the four groups were observed by Tunel method and immunohistochemical method. [Results] Compared with the model group, the apoptotic index and P53 protein expression were decreased, and Bcl-2 protein expression increased in catgut embedding group, acupuncture group and positive control group. [Conclusions] Acupoint catgut embedding therapy can inhibit P53 protein expression, increase Bcl-2 protein expression and inhibit hippocampal neurons, thus reducing the cerebral damage induced by SE. |
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