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| Experimental study on the chief pharmacodynamic effect of Tangju Gao |
| Hits 1389 Download times 1693 Received:December 18, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2007.03.29 |
| Key Words
Tangju Gao;pharmacodynamic effect;experimental research |
| Author Name | Affiliation | | LI Bao-fen | CangZhou Hospital of Integrated Chinese and Western Medicine, CangZhou 061001, China | | CHEN Shu-lan | CangZhou Hospital of Integrated Chinese and Western Medicine, CangZhou 061001, China | | YAN Guo-qiang | CangZhou Hospital of Integrated Chinese and Western Medicine, CangZhou 061001, China |
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| Abstract
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| [Objective] To investigate the chief pharmaocodynamic effect of Tangju Gao(adhesive plaster for treating gangrene of diabetic foot) and provide some theoretic evidences for clinical application. [Methods] The therapeutic effect of Tangju Gao in external application was observed with a model of microcirculatory disturbance induced with adrenaline in mice, a model of auricular swelling induced with dimethylbenzene in mice and a model of swelling of foot metatarsus induced with carrageenin in rats. [Results] Tangju Gao may obviously increase the diameter of the arteriole and venule in the auricula in mice with microcirculatory disturbance, speed up the velocity of blood flow and improve its microcirculation. Tangju Gao may also improve the auricular swelling induced with dimethylbenzene in mice, inhibit the swelling in foot metatarsus induced with carrageenin in rats. [Conclusions] Tangju Gao in external application can improve the auricular microcirculation in mice and may have some anti-inflammatory effects. |
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