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| Experiment study on the therapeutic action of Baicalein for skin hypersensitivity |
| Hits 1799 Download times 2226 Received:December 12, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2007.03.30 |
| Key Words
scutellariae baicalensis;Baicalein;delayed-type hypersensitivity (DTH) |
| Author Name | Affiliation | | HUA Xiao-dong | The Pharmacological laboratory, Tianjin Institute for Drug Control, Tianjin 300070, China | | GONG Yuan-yuan | The Pharmacological laboratory, Tianjin Institute for Drug Control, Tianjin 300070, China | | RUI Jing | The Pharmacological laboratory, Tianjin Institute for Drug Control, Tianjin 300070, China | | 唐元泰 | The Pharmacological laboratory, Tianjin Institute for Drug Control, Tianjin 300070, China |
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| Abstract
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| [Objective] To study the therapeutic effect of Baicalein for skin hypersensitivity. [Methods] The experiments of delayed allergy induced by 2,4-dinitrofluirobenzenz in mice, Forssmam cutaneous vasculitis reaction in guinea pig, homogeneous passive hypersensitivity in mice, titillation induced by low-molecular dextran in mice, foot titillation induced by histamine in guinea pig, contraction test of isolated ileum in guinea pig and pinnal swelling induced by xylene in mice were performed and Baicalein, the effective component of Scutellaria baicalensis, was given by gastric intubation. [Results] Baicalein had significant inhibitory effect on delayed allergy in mice, Forssmam cutaneous vasculitis reaction in guinea pig and passive hepersensitivity in mice. It had the same effect on the titillation in mice, foot titillation in guinea pig simultaneously and inhibited the contraction of isolated ileum and ear swelling in mice also. [Conclusions] Above experiments have demonstrated that Baicalein possesses significant effect of anti-hypersensitivity. It is an antagonistic drug for histamine and has some anti-inflammation effect. |
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