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| Study on fingerprints of radix notoginseng, total saponins and its preparation by HPLC method |
| Hits 1720 Download times 1756 Received:December 27, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2007.03.33 |
| Key Words
radix notoginseng;total saponins;Xuesaitong Sodium Chloride Injection;HPLC;fingerprint;similarity |
| Author Name | Affiliation | | Lin Zhe | Tianjin University of TCM, Tianjin 300193, China | | SUN Yu | Jinan Zhongxin Pharmaceutical Co.Ltd., Jinan 250023, China | | XIAO Xue-feng | Jinan Zhongxin Pharmaceutical Co.Ltd., Jinan 250023, China | | ZHANG Jun-ping | 天津中医药大学第一附属医院, 天津, 300193 | | 毛学建 | 济南中信医药有限公司, 济南, 250023 |
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| Abstract
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| [Objective] To investigate the chromatographic fingerprints of Radix Notoginseng, total saponins and Xuesaitong Sodium Chloride Injection by HPLC, and observe their similarities respectively so as to establish a sensitive and specific method for controlling the quality of Xuesaitong Sodium Chloride Injection. [Methods] The analysis was carried out on Luna C18 column (250 mm×4.6 mm, Ф5 μm) and gradient elution of acetonitrile-water. The detection wavelength was at 203 nm, the flow rate was 1.0 mL/min, the column temperature was set at 30 ℃ and 20 μL sample was injected. The similarity was analyzed by SOP of similarity evaluation system for chromatographic fingerprint of TCM (Version 2004 A). [Results] The HPLC fingerprints of Radix Notoginseng, total saponins and Xuesaitong Sodium Chloride Injection were obtained. The similarity was better. [Conclusions] This method can be used as the standards in testing the fingerprints of Radix Notoginseng, total saponins and Xuesaitong Sodium Chloride Injection, and has provided a criteria in the quality control for Xuesaitong Sodium Chloride Injection. |
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