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| Expression of cTnT induced by Salvianolic Acid B in differentiation of bone marrow Mesenchymal Stem Cells into myocardium-like cell |
| Hits 2118 Download times 1788 Received:February 18, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2007.04.30 |
| Key Words
SalB;MSCs;induction in vitro;cTnT |
| Author Name | Affiliation | | SUN Lian-sheng | Tianjin Hangzhou Road Hospital in Tanggu District, Tianjin 300000, China | | Xu Xiu-mei | Tianjin University of TCM, Tianjin 300193, China | | GUO Mao-juan | Tianjin University of TCM, Tianjin 300193, China | | 赵旭 | Tianjin University of TCM, Tianjin 300193, China | | 苏金玲 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of salvianolic acid B (SalB) in differentiation of bone marrow mesenchymal stem cells (MSCs) into myocardium-like cells. [Methods] MSCs was cultured,purified and evaluated,then MSCs was induced by 5-aza,SalB and 5-aza associating SalB to observe the cells’ morphology change and evaluate the expression of cardiac troponin T (cTnT) by immunocytochemistry method. [Results] After induction,the volume of MSCs increased,the proliferation speed decreased. Myotube-like structure appeared and expressed cTnT. [Conclusions] SalB plays a certain role in the process of induction into myocardium-like cells. |
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