Key Words
Pedo-anti-epilepsy Capsule;epilepsy;pentylenetetrazol lighting model;γ-GABA;GLU
Author Name
Affiliation
TIAN Shu-xia
Tianjin University of TCM, Tianjin 300193, China
LI Xin-min
The First Affiliateed Hospital to Tianjin University of TCM, Tianjin 300193, China
Abstract
[Objective] To observe the change of γ-GABA and Glu content in the brain of epilepsy rats based on the research and explore the effect mechanism of Pedo-anti-epilepsy capsule. [Methods] To observe change of γ-GABA and Glu content in the cerebral cortex and hippocamp of rats by using HPLC and ultra-violet detection method. [Results] The Pedo-anti-epilepsy Capsule had obviously antagonism for pentylenetetrazol lighting and attacking of rats. [Conclusions] The mechanism of action may have related with the change of γ-GABA and GLU content and GABA metabolism in the brain.
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