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| Establishment of Tubulointerstitial Lesion Model in Rat with Mesenteric Proliferative Glomerulonephritis and the Protective Effect of Shenshuning(SSN) |
| Hits 1626 Download times 1899 Received:March 01, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2007.04.32 |
| Key Words
mesenteric proliferative glomerulonephritis;tubulointerstitial lesions;Shenshuning;Model |
| Author Name | Affiliation | | LI Guo-xia | The International College of Integrated Traditional Chinese Medicine and Western Medicine of Tianjin Medical University, Tianjin 300070, China | | HUANG Wen-zheng | The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193, China | | ZHU Xiao-di | The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To establish a new animal model with progressive tubulointerstitial injury (TⅡ) in rats with Mesenteric proliferative glomerulonephritis and observe the protective effect of Shenshuning (SSN). [Methods] After inducing of Mesenteric proliferative glomerulonephritis (MsPGN) the sick rats were allowed survived till 12th -16th weeks and so producing a model tubulointerstitial lesion naturally. With this model the protective effect of the herbal medicine SSN was observed. At the same time,benazepril served as control. [Results] The tubulointerstitial injury was aggravated gradually along with the extension of time in model of rats. SSN and benazepril could distinctly relieve the tubulointerstitial injury. [Conclusions] The model with tubulointerstitial injury has successfully been estalished in rats with mesenteric proliferative glomerulonephritis. The herbal medicine SSN has exhibited distinct protective effect against the tubulointerstitial injury. |
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