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| Anti-tumor effect and effect on p53 and PCNA expression of decoction of branch of Juglans Maxim in mice bearing S180 tumor cells |
| Hits 2169 Download times 1349 Received:March 20, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2007.05.26 |
| Key Words
Juglans Maxim’s branch(DJM);sarcoma-180;p53;PCNA |
| Author Name | Affiliation | | YU Xiao-hong | Heilongjiang University of TCM, Harbin 150040, China | | MEI Lei | Heilongjiang University of TCM, Harbin 150040, China | | YAN Pei-yu | Heilongjiang University of TCM, Harbin 150040, China | | 赵春卉 | Heilongjiang University of TCM, Harbin 150040, China |
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| Abstract
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| [Objective] To study the tumor-resistant effect of the decoction of Juglans Maxim’s branch(DJM) in sarcoma-180 tumor-bearing mice and the influence on the protein expression of p53 gene and proliferating cell nuclear antigen (PCNA).[Methods] The protein contents of p53 and PCNA from bearing sarcpma-180 were determined by immunohistochemistry method.[Results] The tumor inhibitory rate of DJM in tumor-bearing mice was 35.68%; DJM can obviously decrease the expression of p53 and PCNA from sarcoma-180 mice tumor organism when compared with model group (P<0.05).[Conclusions] DJM has conspicuous inhibitory effect to the growth of tumor-bearing mice sarcoma-180 tumor and shows anti-tumor function by restraining the expression of mutant p53 gene and PCNA gene from tumor. |
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