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| Effects of Xinnao Xuemai Ning on serum CRP and inflammatory cell infiltration in plaque in rabbit with vulnerable plaque |
| Hits 2145 Download times 1673 Received:March 16, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2007.05.28 |
| Key Words
vulnerable plaque;serum CRP;inflammatory cell;Xinnao Xuemai Ning |
| Author Name | Affiliation | | JIANG Xi-juan | Department of Pathology, Tianjin University of TCM, Tianjin 300193, China | | DU Yun | Tianjin High Training School of Medicine, Tianjin 300222, China | | SU Jin-ling | Department of Pathology, Tianjin University of TCM, Tianjin 300193, China | | 李妍 | 天津市中医药研究院附属医院, 天津, 300020 | | 张曾罂 | 天津市中医药研究院附属医院, 天津, 300020 | | 范英昌 | Department of Pathology, Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of Xinnao Xuemai Ning (calming heart and brain and blood vessel) on serum CRP and the infiltration of inflammatory cell in plaque of rabbit with vulnerable plaque. [Methods] The vulnerable atherosclerotic plaque model was reproduced by pulling injury of abdominal aorta endothelium combined with high lipid forage. One week later,Xinnao Xuemai Ning was administered to the vulnerable atherosclerotic plaque model for twelve weeks. At the end blood was collected for CRP test by ELISA,then the plaque was disrupted with medico-triggered at 48 h and 24 h before sacrificing the animals. Abdominal aorta plaques were gathered for observation of inflammatory cell infiltration.[Results] The positive correlation was found between the serum CRP and inflammatory cell infiltration in plaque. Xinnao Xuemai Ning could reduce the number of plaque rupture and the level of serum inflammatory CRP. There was significant difference between model group and Xinnao Xuemai Ning group(P<0.05).[Conclusions] Xinnao Xuemai Ning can increase the stability of vulnerable atherosclerotic plaque,Its mechanism of action was correlated with anti-inflammation. |
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