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| Effect of Powder Sini, Xiaoyao and Decoction of Sijunzi on behavior of stressed rats with chronic stagnation of liver-qi |
| Hits 2096 Download times 2400 Received:July 06, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2007.06.30 |
| Key Words
chronic unpredictable mild stress;liver depression;regulating Liver and Spleen;Xiaoyao Powder and Decoction of Sijunzi;sucrose taking rate;forced swimming test |
| Author Name | Affiliation | | YU Qi | | | JIN Guang-liang | |
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| Abstract
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| [Objective] To study the effects of Powder Sini, Xiaoyao and Decoction of Sijunzi on stagnation of liver-qi in rats with chronic unpredictable mild stress(CUMS) and explore the TCM syndrome characteristic of chronic stress rats.[Methods] Male Sprague-Dawley rats were exposed to an unpredictable sequence of mild stressors for 21 days and treated with Sini Powder, Xiaoyao Powder and Decoction of Sijunzi. Body weight, forced swimming test and fluid consumption were investigated during the whole procedure. Serum corticosterone was measured by ELISA.[Results] Rats exposed to CUMS showed decreased sucrose preference and increased time in forced swimming test, increased content of serum corticosterone(P<0.01). Regulating Liver and Spleen, Xiaoyao Powder could prevent theses changes (P<0.01), but Decoction of Sijunzi had no effects(P>0.05).[Conclusions] The model investigated in this chronic stressed rats belongs to liver stagnation syndrome and does not relate to spleen deficiency. |
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