Key Words
periplocin;periplocymarin;cardiac glycoside;metabolism by intestinal bacterium;incubation with intestinal flora;metabolism conversion
Author Name
Affiliation
REN Xiao-liang
XIE Yue-sheng
PAN Gui-xiang
高秀梅
王焱
戚爱棣
Abstract
[Objective] To investigate the change of content and component of periplocin in vitro under the action of intestinal flora in rat and human.[Methods] Periplocin was incubated with intestinal flora from rat and human. HPLC-UV method was used to quantitate the content of Periplocin and their metabolites. HPLC-MS method was used to qualitate the metabolite.[Results] The content of periplocin decreased fast after incubation with intestinal flora. It decreased about 75% after incubation for 5 hours. At the same time, a metabolite appeared, It’s content raised and related with the time of incubation.[Conclusions] Periplocin can be disintegrated fastly into periplocymarin by intestinal bacterium.
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