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| Therapeutic effect of Yishen Qingxin decoction on insomnia and sex hormone secretion in peri-menopausal patients with failure of the heart and kidney for integrating |
| Hits 1854 Download times 3114 Received:December 06, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2008.01.06 |
| Key Words
Perimenopausal period;insomnia;Nurishing kidney clearing heart decoction;sex hormone |
| Author Name | Affiliation | | HE Gui-xiang | The First Clinical College of Nanjing University of TCM, Nanjing 2100046, China | | CHEN Dan | The First Clinical College of Nanjing University of TCM, Nanjing 2100046, China |
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| Abstract
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| [Objective] To observe the therapeutic effect of YishenQingxin(tonifying kidney and clearing heart) decoction(TKCHD) in treating insomnia in peri-menopausal patients with failure of the heart and kidney for integrating and discuss its mechanism for providing some scientific basis for application of TKCHD in clinical treatment. [Methods] Thirty patients with peri-menopausal insomia were selected. The improvement of the insomnia was evaluated by observing changes of Pittsburgh Sleep Quality Index(PSQI) and kupermann fraction. Other symptoms and sex hormone level were detected by observing the changes of serum LH, FSH, E2. [Results] Peri-menopausal insomnia was significantly improved after treatment with TKCHD. The total effective rate was 86.67%. Pittsburgh Sleep Quality Index and kupermann fraction changed remarkably before and after treatment(P<0.01). The serum E2 lever had a raising tendency and the serum LH, FSH level had a tendency to decrease without statistics significance(P>0.05). [Conclusions] NKCHD can effectively treat perimenopausal insomnia and other perimenopausal syndrome. It also can regulate the level of patients’sexual hormone, and is well worth developing and being put into use. |
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