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| Preliminary research on interventional effects of traditional Chinese drug Tangshenqing-1 on glomerular sclerosis in diabetic rats |
| Hits 2047 Download times 1799 Received:November 17, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2008.01.21 |
| Key Words
Tangshenqing-1;diabetes mellitus;ultrastructure;kidney |
| Author Name | Affiliation | | DI Fu-sheng | The Third Center Hospital, Tianjin 300170, China | | WANG Lu | The Third Center Hospital, Tianjin 300170, China | | CHENG Jian-jun | The Third Center Hospital, Tianjin 300170, China | | 丁贤 | The Third Center Hospital, Tianjin 300170, China | | 杨莉 | The Third Center Hospital, Tianjin 300170, China | | 王露 | The Third Center Hospital, Tianjin 300170, China |
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| Abstract
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| [Objective] To observe the effects of traditional Chinese drug Tangshenqing-1 on renal ultrastructure in diabetic rats with glomerular sclerosis. [Methods] Male Wistar rats were randomly divided into 2 groups:normal control group and diabetic group. Diabetes was induced by intra-abdominal injection of alloxan. Four weeks later, diabetic rats were further divided into 2 sub-groups:group of diabetic rats treated with Tangshenqing-1 and diabetic untreated control group. Renal ultrastructure of each group was observed before and after Tangshenqing-1 treatment for 4 weeks, 8 weeks, 12 weeks and 16 weeks respectively. [Results] The ultrastructure examination showed thickening of the glomerular basement membrane (GBM), proliferation of mesenterium and mesangial cells in diabetic control group. Above changes, however, were ameliorated more seriously in Tangshenqing-1-treated group. [Conclusions] Tangshenqing-1can prevent the progress of renal pathological changes in diabetic rats. It is suggested that Tangshenqing-1 may have some protective effects on kidney. |
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