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| Effect of pineal gland on the seasonal changes of T lymphocyte proliferation rate of spleen in rats |
| Hits 1479 Download times 1537 Received:August 16, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2008.01.23 |
| Key Words
pineal gland;spleen;T lymphocyte translation rate;season;immunity |
| Author Name | Affiliation | | YUAN Wei-ling | College of Basic Medical Sciences, Beijing University of Traditional Chinese Medicine, Beijing 100029, China | | MA Shu-ran | College of Basic Medical Sciences, Beijing University of Traditional Chinese Medicine, Beijing 100029, China | | GUO Xia-zhen | College of Basic Medical Sciences, Beijing University of Traditional Chinese Medicine, Beijing 100029, China | | 李晓君 | College of Basic Medical Sciences, Beijing University of Traditional Chinese Medicine, Beijing 100029, China | | 刘晓燕 | College of Basic Medical Sciences, Beijing University of Traditional Chinese Medicine, Beijing 100029, China | | 顾晓静 | College of Basic Medical Sciences, Beijing University of Traditional Chinese Medicine, Beijing 100029, China | | 徐巍华 | College of Basic Medical Sciences, Beijing University of Traditional Chinese Medicine, Beijing 100029, China | | 赵树宏 | College of Basic Medical Sciences, Beijing University of Traditional Chinese Medicine, Beijing 100029, China |
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| Abstract
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| [Objective] To investigate the effects of pineal gland on the seasonal changes of T lymphocyte translation rate of spleen in rats. [Methods] T lymphocyte proliferation rate of spleen by MTT method in winter and spring in Wistar rats of pinealectomy was determined. [Results] T lymphocyte proliferation rate of normal group, shame operation group and operation group in vernal equinox was significantly lower than that of respective groups in winter solstice (P<0.01). The value of normal group was significantly higher than that of shame group in winter solstice(P<0.01). The value of shame group was significantly higher than that of operation group in vernal equinox (P<0.01). T lymphocyte translation rate of shame operation group and operation group in winter solstice and vernal equinox was lower than that of normal groups. Specially, the value of operation group was significantly lower than that of normal group in winter and spring (P<0.01). [Conclusions] There is a tendency that T lymphocyte translation rate of spleen is higher in winter and lower in spring. In spring, Pinealectomy can significantly reduce the spleen immunity. The effects of pineal gland on the seasonal changes of T lymphocyte translation rate is not uniqueness. |
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