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| Inhibitory effect of indirubin on growth of some cancer cells and its mechanism |
| Hits 1605 Download times 2159 Received:September 10, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2008.01.26 |
| Key Words
indirubin;cancer;cell cycle;kinase |
| Author Name | Affiliation | | WU Qi-wei | Beijing Shijingshan Hospital, Beijing 100043, China | | GE Zhong-liang | Institute of Radiation Medicine of Academy of Military Medical Sciences, Beijing 100850, China | | GAO Yue | Institute of Radiation Medicine of Academy of Military Medical Sciences, Beijing 100850, China | | 张丽 | Beijing University of TCM, Beijing 100029, China |
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| Abstract
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| [Objective] The inhibitory effect of indirubin on cell growth was studied in some human tumor cell lines relating with cyclin-dependent kinases(CDK) or Src kinase. [Methods] The cell growth, such as leukemia cell line(K562), gastric cancer cell line, lymphoma cell line, uterine cervix cancer cell line, promyelocyte leukemia cell line(HL-60), carcinoma of gallbladder cell line, hepatocarcinoma cell line, hilar cholangiocarcinoma cell line was proved inhibited by indirubin using clone cell culture method. The influence of indirubin on the K562 cell line, the gallbladder cancer cell and hilar cholangiocarcinoma cell line was observed with MTT method. [Results] The inhibitory effect of indirubin was verified extensively in some cancer cell growth. [Conclusions] Indirubin and its derivatives may become the new anti-tumor medicine for therapy of cancers that have CDK, Src kinase. |
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