|
| Influence of Salvianolic acid B on serum SOD activities and MDA concentrations in rats with focal cerebral ischemia-reperfusion |
| Hits 1552 Download times 1805 Received:September 30, 2007 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2008.01.29 |
| Key Words
salvianolic acid B;cerebral ischemia;reperfusion;superoxide dismutase;malondialdehyde |
| Author Name | Affiliation | | ZHAO Xu | Tianjin University of TCM, Tianjin 300193, China | | FAN Ying-chang | Tianjin University of TCM, Tianjin 300193, China | | DU Yun | Tianjin University of TCM, Tianjin 300193, China |
|
| Abstract
|
| [Objective] To study the effects of salvianolic acid B on the serum superoxide dismutase (SOD) activities and malondialdehyde (MDA) concentrations in rats with focal cerebral ischemia-reperfusion injury and analyze the mechanism of action of salvianolic acid B in preventing and treating ischemic cerebrovascular disease. [Methods] Twenty-four healthy male Wistar rats were randomly divided into three groups with eight rats in each group:sham operation group, model group, salvianolic acid B groups. The latter group was infused with corresponding drugs once a day for seven days. Then the intraluminal suture technique was used to establish the models of middle cerebral artery occlusion (MCAO) for 2 h of occlusion and 24 h of reperfusion in rats except sham-operation group. At the end of reperfusion, the extent of neurological deficits was evaluated by Longa’s model. And the serum SOD activities and MDA concentrations were monitored after the focal cerebral ischemia-reperfusion. [Results] In model group, the score of neurological deficits was raised, serum SOD activities were decreased and serum MDA concentrations were increased. Salvianolic acid B could reduce the score of neurological deficits, increase serum SOD activities and decrease MDA concentrations. [Conclusions] Salvianolic acid B can improve neurological function of rats with focal cerebral ischemia-reperfusion injury, reduce the consumption of antioxidase, promote the elimination of free radical and relieve lipid peroxidation reaction. |
|
|
|
|
|
|
|
