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| Correlation between ApoA1 gene polymorphism and efficacy of Qishen Yiqi dripping pill |
| Hits 1564 Download times 1726 Received:November 17, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2008.02.05 |
| Key Words
Apolipoprotein A1(ApoA1);single nucleotide polymorphism;Qishen Yiqi dripping pills;qi deficiency and blood stasis type of coronary heart disease |
| Author Name | Affiliation | | ZHAO Guang-rong | Department of Pharmaceutical Engineering, College of Chemical Engineering and Technology of Tianjin University, Tianjin 300072, China | | ZHANG Heng-ming | Department of Pharmaceutical Engineering, College of Chemical Engineering and Technology of Tianjin University, Tianjin 300072, China | | XIAO Min | Department of Pharmaceutical Engineering, College of Chemical Engineering and Technology of Tianjin University, Tianjin 300072, China | | 李欲来 | 天津中医药大学 天津 300193 | | 张军平 | 天津中医药大学 天津 300193 |
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| Abstract
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| [Objective] To explore the relationship between single nucleotide polymorphism(SNP) of apolipoprotein A1(ApoA1) gene and efficacy of Qishen Yiqi(QSYQ) dripping pills on qi deficiency and blood stasis type of coronary heart disease.[Methods] Forty-two patients received QSYQ dripping pills for one month.The syndromes were scored,and blood samples were taken before and after treatment.The contents of blood fat,blood sugar and apoA and apoB were detected and the DNA was extracted from the leukocyte of the blood samples,and then the first extron of ApoA1 gene was amplified by polymerase chain reaction.The polymorphic site was detected by sequencing.[Results] Four significant mutant sites were found in ApoA1 gene.Between mutant groups and normal groups,the subtract values of deficiency of vital energy,lassitude,spontaneous perspiration,chest pain,suffocative sensation in the chest,palpitation,dark purple face and total syndrome score weren’t significantly different(P>0.05).The subtract values of blood glucose,triglyceride,and apolipoproteins weren’t also significantly different(P>0.05).[Conclusions] Four SNP sites in ApoA1 cann’t affect the efficacy of QSYQ dripping pills on qi deficiency and blood stasis type of coronary heart disease. |
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