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| Acupuncture effect on age-related change of p38 expression in hippocampus neocortex in SAMP10 Mice |
| Hits 1621 Download times 1600 Received:September 20, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2008.02.13 |
| Key Words
YiqiTiaoxue and FubenPeiyuan;age-accelerated Mouse(SAMP10);Western blotting;neocortex;hippocampus;age-related change;p38 |
| Author Name | Affiliation | | LIU Tao | The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China | | YU Jian-chun | The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China | | HAN Jing-xian | The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To explore the effect mechanism of acupuncture.[Methods] SAMP10 was used as model mouse and SAMR1 as normal control mouse.Western blotting technique was used to monitoring the difference of age-related p38 expression in neocortex and hippocampus between R1 and P10.The effect of YiqiTiaoxue and FubenPeiyuan acupuncture on the protein expression in 8-month old P10 brain was observed.[Results] The p38 expression had a stable age-related uprising tendency in the neocortex and hippocampus of R1 control.In P10,p38 expression exhibited an fluctuating age-related uprising tendency.These changes occurred at 4 to 6 month old and went on at the following months.In the hippocampus and neocortex of 8-month old P10,p38 expression exhibited a higher level than that of R1.The acupuncture of YiqiTiaoxue and FubenPeiyuan could reverse the difference mostly,the non-points group had no the same effect.[Conclusions] There is a difference in p38 expression in the same part of the brain between P10 and R1.The period of age-related changing is very approximate in the p38 expression and the onset of age-accelerated characters.The acupuncture of YiqiTiaoxue and FubenPeiyuan can effectively down-regulate the high level expression of p38 in 8-month old P10. |
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