|
| Mechanism of Yougui pills in ameliorating the free radical peroxidation injury in Vivo in rats with hypothyroidism |
| Hits 1724 Download times 1906 Received:November 05, 2007 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2008.03.27 |
| Key Words
Hypothyroidism;TCM therapy;SOD;Yougui pill |
| Author Name | Affiliation | | JIA Xi-lian | General Hospital of Tianjin Medical University, Tianjin 300070, China | | QU Zhu-qiu | General Hospital of Tianjin Medical University, Tianjin 300070, China | | YAO kai | General Hospital of Tianjin Medical University, Tianjin 300070, China | | 卢秀鸾 | General Hospital of Tianjin Medical University, Tianjin 300070, China |
|
| Abstract
|
| [Objective] To investigate the mechanism of Yougui pills in lightening free radical peroxidative damage in rats with hypothyroidism. [Methods] Propylthiouracil intragastric dosage was adopted to result in experimental hypothyroidism in rat. Eight weeks later they were sacrificed and their blood was harvested to detect the function of thyroid gland and also the hepatocuprein (SOD) in blood serum. The thyroid gland tissue was obtained to determine the hepatocuprein (SOD) in it. [Results] The activity of SOD in hypothyroidism rats descended significantly. Yougui pills and the thyroid tablet up-regulated the activity of SOD significantly after treatment. The effectiveness of the thyroid tablet was better. Correlation analysis result displayed that the activity of SOD and T3, T4, FT3, FT4 were in significant positive correlation(P<0.01). Negative correlation was fund between the activity of SOD and TSH (P<0.05). But SOD in the glandular tissue of hypothyroidism rats was higher. Yougui pills and the thyroid tablet could improve the exorbitance of SOD to normal level. The effectiveness of Yougui pills was better. [Conclusions] Yougui pills can increase the reactive stress ability of lipid peroxidation in rats with hypothyroidism. It has some effect in decreasing the free radical peroxidation damage in the body. |
|
