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| Experimental study of different DGBXT preparation on hematopoiesis regulation in mice with myelosuppression |
| Hits 1627 Download times 2511 Received:December 03, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2008.03.28 |
| Key Words
Danggui Buxue decoction;granule formulation;myelosuppression;hemotopoietic regulation |
| Author Name | Affiliation | | YAN Su-chun | Department of TCM, The General Hospital of Tianjin Medical University, Tianjin 300052, China | | ZHU Bi-de | Department of TCM, The General Hospital of Tianjin Medical University, Tianjin 300052, China | | HAN Ying-guang | Department of TCM, The General Hospital of Tianjin Medical University, Tianjin 300052, China | | 郭巍 | Department of TCM, The General Hospital of Tianjin Medical University, Tianjin 300052, China |
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| Abstract
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| [Objective] In order to provide some experimental evidences for new herb dosage form, the aim of this experement is to compare the effect of Dang-gui Bu-xue decoction (DGBXT) decoction with that of granule formulation for treating myelosuppression in mice. [Methods] Hemopoietic progenitor cell culture and peripheral blood count was used to analyze the hemopoietic function of bone marrow. The hemopoietic factors in bone marrow microenvironment were also tested by ELISA. [Results] The ways to improve the account of peripheral blood and nucleated bone marrow cells and to yield the hematopoietic stem / progenitor cells in vitro colony were balancing the expression of cytokine (EPO, TPO, GM-CSF) in bone marrow microenvironment. To facilitate hematopoietic stem/progenitor cells entering the cell cycle is also necessary. But the effect of granule formulation seems to be more better. [Conclusions] All DGBXT decoction and the granule formulation can improve the hematopoietic function of bone marrow suppression in mouse. The curative effect of DGBXT granule was more outstanding than that of DGBXT decoction. |
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