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Effect of Jiashen Qiangxin prescription on heart function of CHF rats
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DOI   10.11656/j.issn.1672-1519.2008.04.20
Key Words   Jiashen Qiangxin prescription;congestive heart failure;heart function
Author NameAffiliation
XU Qiang The Second Hospital Affiliated to Tianjin University of TCM, Tianjin 300150, China 
GAO Xiu-mei Tianjin University of TCM, Tianjin 300193, China 
WANG Bao-he Tianjin University of TCM, Tianjin 300193, China 
郭志军 Tianjin University of TCM, Tianjin 300193, China 
Abstract
    [Objective] To assess the effects of Jiashen Qiangxin prescription on heart morphology and function of CHF model rat, and try to find out the effect mechanism. [Methods] The CHF rat model was established by ligation of anterior descending branch of coronary artery, then treated with Chinese herbs Qiangxinpian and observed the change of heart function with UCG. [Results] CHF rats had obvious symptoms of heart failure with a lower EF value. After treating for 4 weeks with Jiashenqiangaxin tablet the function of left ventricle was improved. In the group of Jiashen Qiangxin prescription and captopril, LVDd was 6.25±0.28mm and 6.05±0.45mm,LVDs was 3.28±0.18mm and 3.57±0.27mm; At the same time, EF value was improved from 56.03±2.59 to 80.28±3.06 in the group of Jiashen Qiangxin prescription (P<0.05). [Conclusion] Jiashen Qiangxin prescription can improve the function of CHF, and has benefit effect for ventricular remodeling.

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