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Effect of Jiashen Qiangxin prescription on heart function of CHF rats |
Hits 1616 Download times 1484 Received:March 11, 2008 |
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DOI
10.11656/j.issn.1672-1519.2008.04.20 |
Key Words
Jiashen Qiangxin prescription;congestive heart failure;heart function |
Author Name | Affiliation | XU Qiang | The Second Hospital Affiliated to Tianjin University of TCM, Tianjin 300150, China | GAO Xiu-mei | Tianjin University of TCM, Tianjin 300193, China | WANG Bao-he | Tianjin University of TCM, Tianjin 300193, China | 郭志军 | Tianjin University of TCM, Tianjin 300193, China |
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Abstract
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[Objective] To assess the effects of Jiashen Qiangxin prescription on heart morphology and function of CHF model rat, and try to find out the effect mechanism. [Methods] The CHF rat model was established by ligation of anterior descending branch of coronary artery, then treated with Chinese herbs Qiangxinpian and observed the change of heart function with UCG. [Results] CHF rats had obvious symptoms of heart failure with a lower EF value. After treating for 4 weeks with Jiashenqiangaxin tablet the function of left ventricle was improved. In the group of Jiashen Qiangxin prescription and captopril, LVDd was 6.25±0.28mm and 6.05±0.45mm,LVDs was 3.28±0.18mm and 3.57±0.27mm; At the same time, EF value was improved from 56.03±2.59 to 80.28±3.06 in the group of Jiashen Qiangxin prescription (P<0.05). [Conclusion] Jiashen Qiangxin prescription can improve the function of CHF, and has benefit effect for ventricular remodeling. |
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