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| Effect of salvianolic acid B on apoptosis of myocardial cells in rats with nyocardial infarction |
| Hits 2143 Download times 1885 Received:May 11, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2008.04.21 |
| Key Words
salvianolic acid B;myocardial infarction;myocardial cell;apoptosis |
| Author Name | Affiliation | | ZHANG Meng | The TCM College of Tianjin University of TCM, Tianjin 300193, China | | WANG Yi | The Academy of TCM of Tianjin University of TCM, Tianjin 300193, China | | WANG Hong | The Academy of TCM of Tianjin University of TCM, Tianjin 300193, China | | 王少侠 | The Academy of TCM of Tianjin University of TCM, Tianjin 300193, China | | 柴丽娟 | The Academy of TCM of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the inhibitory effects and mechanism of Salvianolic acid B (Sal B) on apoptosis of myocardial cells in rats with acute myocardial infarction. [Methods] We produced myocardial infarction in anaesthetized rats by occluding the left descending coronary artery. Sham-operated rats served as controls. We assayed the myocardial cell apoptosis and the gene expressions by flow cytometry and real-time RT-PCR. [Results] Sal B can decrease the number of apoptotic myocytes and decrease the expression of IL-6, Bax and STAT-3. [Conclusion] Sal B can limit the myocardial cell apoptosis after infarction and the mechanism may be related to the down regulation of the apoptosis relative genes expression. |
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