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| Experimental study on skin stimulation and hypersensitivity of Guzhining gel |
| Hits 1841 Download times 1702 Received:December 23, 2007 |
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| DOI
10.11656/j.issn.1672-1519.2008.04.23 |
| Key Words
Guzhining gel;skin irritation;hypersensitiveness |
| Author Name | Affiliation | | CHEN Li-jiang | College of Pharmacy, Liaoning University, Shenyang 110036, China | | ZHANG Sheng | Liaoning Institute of Pharmaceutical Industry, Shenyang 110015, China | | MENG Fan-rui | College of Pharmacy, Liaoning University, Shenyang 110036, China | | 刘宇 | College of Pharmacy, Liaoning University, Shenyang 110036, China | | 张影 | College of Pharmacy, Liaoning University, Shenyang 110036, China | | 王欣 | College of Pharmacy, Liaoning University, Shenyang 110036, China | | 刘冰弥 | College of Pharmacy, Liaoning University, Shenyang 110036, China |
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| Abstract
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| [Objective] For evaluating the safety of the drug we investigate the skin irritation and hypersensitiveness of Guzhining gel. [Methods] The skin irritation experiment was carried out by comparing the irritation on skin of both sides of rabbits, and the skin hypersensitive experiment was carried out on guinea pigs. [Results] Guzhining gel had no irritation effect on the integral skin of rabbits, but a little irritation on damaged skin of rabbits was observed. Hypersensitive effect on the skin of guinea pig was not found, but the positive vehicle drug 2, 4-dichloronitrobenzene had strong hypersensitiveness. [Conclusion] Guzhining gel has no irritation on normal skin of rabbits and hypersensitiveness on guinea pigs, thus it may be used topically. However, it should be curious or avoided to use on damaged skin because of a little irritation on injured skin. |
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