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| Pharmacokinetic study of jasminoidin in Huanglianjiedu decoction in rats |
| Hits 2470 Download times 2188 Received:January 06, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2008.04.26 |
| Key Words
Huanglianjiedu decoction;jasminoidin;HPLC;pharmacokinetic |
| Author Name | Affiliation | | Xiao Xuefeng | Tianjin University of TCM, Tianjin 300193, China | | Qiao Xiaoli | Tianjin Nankai Hospital, Tianjin 300100, China | | Gao Lan | Tianjin University of TCM, Tianjin 300193, China | | 张军平 | 天津中医药大学第一附属医院, 天津, 300193 | | 孙瑜 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To study the pharmacokinetics of Jasminoidin in Huanglianjiedu Decoction in rats. [Methods] HPLC detection was used to determine the Jasminoidin levels in biological samples. [Results] After giving Jasminoidin orally in rats, the plasma concentration-time course fitted well to two-compartment model and with following pharmacolinetic parameters: α=(0.03±0.01)/min, β=(0.000 6±0.000 2)/min,t1/2α=(79.02±22.38) min,t1/2β=(13 031.81±8 817.76) min,T(peak)=(99.46±28.73) min,Cmax=(5.02±1.52) mg/L,AUC=(69 334.66±15 565.92) mg/(L·min). [Conclusion] The pharmacokinetic characteristics of Jasminoidin in Huanglianjiedu Decoction in rats was identified, providing evidence for clinical medication of Huanglianjiedu decoction. |
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