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| Effect of salvianolic acid A on ICAM-1 expression after Hypoxia/ Reoxygenation injury in brain microvascular endothelial cells |
| Hits 1585 Download times 1846 Received:May 06, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2008.05.26 |
| Key Words
Salvianolic Acid A;hypoxia/reoxygenation;ICAM-1;RT-PCR |
| Author Name | Affiliation | | JIANG Min | Tianjin University of TCM, Tianjin 300193, China | | GUO Li-ping | Tianjin University of TCM, Tianjin 300193, China | | ZHONG Wang-yi | Tianjin University of TCM, Tianjin 300193, China | | 李晶 | Tianjin University of TCM, Tianjin 300193, China | | 王婕 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the action of Sal A on the expression of cellular adhesion molecules after hypoxia/reoxygenation (H/R) injury in brain microvascular endothelial cells (BMEC). [Methods] After pretreating with Sal A for 20h, the H/R was successfully established H/R on BMEC. Then the expression of ICAM-mRNA was evaluated by RT-PCR method. Nimodipine served as positive control.[Results] Compared with control, the expression of ICAM-mRNA of H/R model enhanced significantly (P<0.01). Sal A could downregulate the expression of ICAM-1 in the H/R model on BMEC (P<0.05). [Conclusion] Sal A can downregulate the expression of ICAM-1 in the H/R injured BMEC, suggesting that the molecular mechanism of Sal A in brain protection was based on down-regulating the expression of cellular adhesion molecules. |
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