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| Study on protectve and reparing effect of "Xinshenyihao" in mucosa of rats with gastric ulcer |
| Hits 1659 Download times 2200 Received:April 03, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2008.05.27 |
| Key Words
Gastric Ulcer;Apoptosis;Bcl-2;Bax;Xinshenyihao |
| Author Name | Affiliation | | BAI Li-jun | Tianjin Medical University, Tianjin 300070, China | | JIA Xi-lian | The General Hospital of Tianjin Medical University, Tianjin 300052, China | | WU Cheng | The Affiliated Hospital of Tianjin Academy of TCM, Tianjin 300120, China | | 刘志云 | 天津市残疾人康复服务指导中心 天津 300381 |
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| Abstract
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| [Objective] To study the pharmacological action and mechanism of "Xinshenyihao" (XS-1) in treating rats with experimental gastric ulcer. [Methods] Gastric ulcer was induced in rats by using soaking and restraining stress and acetic acid damage to study the function of XS-1 in protecting and repairing gastric ulcer, and the effect of XS-1 on the expression of Bcl-2 and Bax in rats with gastric ulcer was also determined. [Results] XS-1 played a significantly role in treating both acetic ulcer and in preventing stress ulcer. In both model groups, Bcl-2 positive cells in the XS-1 treated groups were significantly more than those in the model groups (P<0.01). In contrast,Bax positive cells in the model groups were significantly more than those in the XS-1-treated groups (P<0.01). [Conclusion] The traditional Chinese medicine Xinshenyihao can enhance the expresstion of Bcl-2 and reduce the expresstion of Bax in mucosa of rats with gastric ulcer. This might be one of its mechanisms. |
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