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| Controlled study on the leukoaraiosis with mild cognitive impairment |
| Hits 2356 Download times 2083 Received:August 10, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2008.06.04 |
| Key Words
Leukoaraiosis;mild cognitive impairment;case-controlled study |
| Author Name | Affiliation | | CHEN Bao-xin | Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | ZHANG Yun-ling | Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | JIN Xiang-lan | Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 陈志刚 | Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 郭蓉娟 | Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 侯小兵 | Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 高芳 | Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 戴中 | 北京大学人民医院, 北京, 100044 | | 柳洪胜 | 北京大学人民医院, 北京, 100044 | | 谢颖桢 | 北京中医药大学附属东直门医院, 北京, 100700 | | 王麟鹏 | 首都医科大学附属北京中医医院, 北京, 100010 | | 郭静 | 首都医科大学附属北京中医医院, 北京, 100010 |
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| Abstract
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| [Objective] To investigate the risk factors and clinical features of leukoaraiosis(LA) with mild cognitive impairment. [Methods] Case-controlled study was adopted in the study in 35 patients of LA with mild cognitive impairment matched in age and sex with 35 patients of LA without cognitive impairment. [Results] The logistic regression analysis of the multiple factors (backward method) showed that the OR of education level, exercise, mental work, family history of stroke and hyperlipidemia were 0.395, 0.278, 0.404, 2.865, 5.988. There was negative correlation between cognitive impairment and education level, exercise, mental work. The patients of LA with mild cognitive impairment had lower score of calculating ability, short-term memory, visual-spatial ability. Symptoms as follows were more fre-quent in the group of LA with mild cognitive impairment:dysphoria, dry mouth, dry eyes, heavy body, sticky and greasy in mouth, sighing, tidal fever and night sweating, enuresis when cough and laugh happened. The deficiency of qi, blood, yin, yang and phlegm, stagnation blood, fire, depression were equally exist in the two groups. [Conclusion] High education level, mental work and exercise are protecting factors of cognition, while family history of stroke and hyperlipidemia are risk factors. There was more than one cognitive domain disorder among the patients of LA with cognitive impairment. The pathogenesis of LA with mild cognitive impairment are complicated with both deficiency and excess existed. |
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