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| Influences of electric acupuncture on malondialdehyde and acetylcholinesterase in cerebral tissues of rats with vascular demention |
| Hits 1757 Download times 1906 Received:March 17, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2008.06.10 |
| Key Words
Demention;acup-moxther;Disease models;Animal;Malondiadehyde;Acetylcholinesterase |
| Author Name | Affiliation | | LIU Yan | The Second Hospital of Chao-yang district, Beijing 100026, China | | LI Wei-dong | Department of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, Beijing 100029, China | | Miao Jin | Department of Pediatrics, Shanxi College of TCM, Xianyang 712046, China | | 邓春雷 | 陕西中医学院针灸推拿系, 咸阳, 712046 |
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| Abstract
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| [Objective] To explore the effect of electric acupuncture on the level of malondialdehyde, acetylcholinesterase in cerebral tissues in rats with demention. [Methods] Vascular dementia in rat was established by reperfusion following cerebral global ischemia using a modified Pulsinelli-4-vessel occlusion method. Thirty-two rats were randomly divided into 4 groups:sham-operated control group, mod-el group, electroacupuncture group, Piracetan group. They were treated with electroacupuncture, Piracetan, respectively. Histological survey was carried out to detect the contents of MDA and AchE in cerebral tissue after treatment. Y-type maze was used to measure the behavior of the rats. [Results] The scores of Y-type maze of the model group are apparently less than that of sham-operated group (P<0.05). The level of the malomdialdehyde, acetylcholinesterase increased in cerebral tissue of model group compared with sham-operated group(P<0.05). The levels of the malomdialdehyde, acetylcholinesterase in cerebral tissue decreased compared with model group(P<0.05) after treatment. The scores of Y-maze of all treatment groups were higher than that of model group (P<0.05),which is not different from sham-operated.(P>0.05). [Conclusion] Electroacupuncture can apparently improve the learning and memory ability of rats with demention and the mechanism may be that electroacupuncture can improve antioxidative ability and inhibit active oxygen injury to relieve the cerebral tissues and the reaction of free radicals. Eventually it can improve the ability of learning and memory of rats with demention. |
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