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| Effect of Xufudaizhe decoction on morphology of esophagus mucosa of rats with reflux esophagitis |
| Hits 1667 Download times 1966 Received:July 12, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2008.06.21 |
| Key Words
Xuanfudaizhe decoction;reflux esophagitis;esophageal mucosa;histomorphology |
| Author Name | Affiliation | | YANG You-xin | Tianjin University of TCM, Tianjin 300193, China | | YUAN Hong-xia | Tianjin University of TCM, Tianjin 300193, China | | WEI Ai-qin | Tianjin Nankai TCM Hospital, Tianjin 300100, China | | 代二庆 | 武警医学院附属医院, 天津, 300153 | | 马艳 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of Xuanfudaizhe decoction on the appearance of esophagus mucosa morphology in rats with reflux esophagitis. [Methods] Eighty Wistar rats were randomly divided into four groups:normal control group, model group, traditional Chinese medicine treatment group, Western medicine control group. Duodenum’ end-oesophagus anastomosing was performed in rats of latter three groups. One week after the operation the rats in the three groups were given with 0.9% normal saline, Xuanfudaizhe decoction and mosapride citrate disptrsible tablet suspension respectively. The esophagus mucosa morphology was detected after continuous medication for 21 days. [Results] The gross and pathological integral were the highest in the model group and the lowest the normal control group. There was a significant difference between them. The gross and pathological integral decreased significantly in the traditional Chinese medicine treatment group and Western medicine control group and there was no significant difference between them. But there was a significant difference comparing them with model group and there was no significant difference comparing them with normal control group. [Conclusion] Xuanfudaizhe decoction has a good therapeutic effect on reflux esophagitis in rats. It can significantly improve esophageal mucosa injury and pathological condition in histomorphology. |
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