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| Effect of Tianma Gouteng decoction on the blood pressure in rats with renal angiogenic hypertension |
| Hits 1606 Download times 2023 Received:April 06, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2008.06.27 |
| Key Words
Tianma Gouteng Decoction;renal angiogenic hypertension;blood pressure |
| Author Name | Affiliation | | HU Shi-yun | Guangdong Province Hospital of TCM, Guangzhou 510120, China | | XIAN Shao-xiang | The First Hospital Affiliated to Guangzhou University of TCM, Guangzhou 510120, China | | ZHAO Li-cheng | The First Hospital Affiliated to Guangzhou University of TCM, Guangzhou 510120, China | | 于泽 | The First Hospital Affiliated to Guangzhou University of TCM, Guangzhou 510120, China | | 伍耀衡 | Guangdong Province Hospital of TCM, Guangzhou 510120, China | | 齐玉焕 | Guangdong Province Hospital of TCM, Guangzhou 510120, China |
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| Abstract
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| [Objective] To explore the effects of Tianma(RHIZOMA GASTRODIAE) Gouteng(RAMULUS UNCARIAE CUM UNCIS) decoction on blood pressure in rats with renal angiogenic hypertension. [Methods] Forty-eight male SD rats were randomly divided into the sham-operation group, the model group, the captopril group and the Tianma Gouteng decoction group. Five weeks after modeling, the rats were treated with drugs and persisted for eight weeks. The BP in every group was determined to confirm the effect of decreasing blood pressure. [Results] After four weeks, the blood pressure of the model group rats was obviously ascended (P<0.001), left kidney weight (LK),LK/RK descended(P<0.001) and right kidney weight(RK) was obviously increased(P<0.001), these all confirmed that the modeling was succeeded. After 8 weeks of treatment, the blood pressure level of the captopril and the Tianma Gouteng Decoction group decreased or closed to normal blood pressure (P<0.01). The effect of descending blood pressure of captopril was better (P<0.05). [Conclusion] Through the research, we confirmed that Tianma Gouteng Decoction can decrease blood pressure in rats with renal angiogenic hypertension. |
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