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| Effect of Xinnaoshutong capsule on monoamine neurotransmitter in Cortex in rats with cerebral ischemia and reperfusion |
| Hits 2087 Download times 1930 Received:June 06, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2008.06.29 |
| Key Words
acute cerebral ischemia and reperfusion;pathomorphology;monoamine neurotransmitter;Xinnaoshutong capsule |
| Author Name | Affiliation | | TAO Ye | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | ZHANG Yun-ling | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | LIU Chao | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 王新祥 | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 刘雪梅 | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 郑宏 | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | 闫妍 | The Dongfang Hospital of Beijing University of TCM, Beijing 100078, China |
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| Abstract
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| [Objective] To research the effect of Xinnaoshutong(dredging heart and brain) capsule (XNST), a Chinese medicine with effect of activating blood circulation,removing stasis and dredging collateral), on monoamine neurotransmitter in rats with cerebral ischemia and reperfusion injury. [Methods] Forty-two male SD rats were randomly divided into sham,model,XNST treatment group. Acute cere-bral ischemia and reperfusion was induced with thread occlusion technique inducing middle cerebral artery occlusion in rats. Changes of cortical neurons was determined by HE staining and the concentrations of the monoamine neurotransmitters was measured by HPLC. [Results] Xinnaoshutong capsule had following effects:alleviate the pathological injury and reduce contents of E,DA and 5-HT. [Conclusion] Xinnaoshutong capsule can alleviate the change of pathological injury and the mechanism, underlying the possible protective mechanism is to improve disturbed neurotransmitters. |
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