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| Investigation of HP-β-CD on corneal permeability of baicalin in vitro |
| Hits 1651 Download times 1617 Received:August 11, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2008.06.30 |
| Key Words
HP-β-CD;corneal permeability;Baicalin |
| Author Name | Affiliation | | ZHANG Xin-hua | Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China | | LIU Zhi-dong | Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China | | ZHANG Bo-li | Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China | | 舒乐新 | Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China | | 高秀梅 | Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China |
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| Abstract
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| [Objective] To explore the use of HP-β-CD as a preparation in ophthalmology. [Methods] The effects of HP-β-CD on the corneal permeability for Baicalin were investigated in vitro in isolated corneas of rabbit. [Results] The 11% and 15% HP-β-CD could in-crease the appeared permeability for Baicalin as much as 1.66 and 1.33 times respectively, when compared with the one in the control (P<0.05). However, 7.0% and 20% HP-β-CD didn’t improve the appeared permeability for Baicalin (P>0.05). [Conclusion] The 11% and 15% HP-β-CD enhance the corneal appeared permeability for Baicalin significantly and have not irritation to eye tissues. |
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