|
| Influence of supplementing Qi,activating blood flow and detoxicating on P-glucoprotein in colon tissue in patients with recurrent ulcerative colitis |
| Hits 1812 Download times 1767 Received:October 10, 2008 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2009.01.07 |
| Key Words
ulcerative colitis;anti-recurrence;supplementing Qi;activating blood flow and detoxicating;P-glucoprotein |
| Author Name | Affiliation | | AN He-jun | Dongzhimen Hospital, University of the Traditional Chinese Medicine, Beijing 100029, China | | Yu Mei | 北京中医药大学东直门医院 北京 100700 | | Wang Xin-yue | 北京中医药大学东直门医院 北京 100700 | | 林芳冰 | 北京中医药大学东直门医院 北京 100700 | | 李晓林 | 北京中医药大学东直门医院 北京 100700 | | 王玉芬 | 北京中医药大学东直门医院 北京 100700 |
|
| Abstract
|
| [Objective] To investigate the influence of supplementing Qi, activating blood flow and detoxicating treating on P-glucoproteinexpression in colon tissue of patients with recurrent ulcerative colitis (UC).[Methods] Ninety cases with recurrent UC were randomlydivided into treatment group (n=45) and control group (n=45) according to the random table.After treatment for three months, the cases ofcomplete remission and of with effective treatment were followed-up for 6 months. (treatment group, n=39;control group, n=32).Thepatients of treatment group accepted decoction of supplementing Qi, activating blood flow and detoxicating treatment while the controlgroup used Salazosulfapyridine.[Results] There were obvious differences between treatment group and control group.Before treatment,the level of colon tissue P-glucoprotein in UC group was much higher than that in health persons (P<0.01);the level of P-glucoprotein inrecurrent group was higher than that in non-recurrent group (P<0.01);but after treatment and follow-up period, the level of colon tissueP-glucoprotein in treatment group was lower than that in control group (P<0.01).[Conclusion] The study shows that decoction ofsupplementing Qi, activating blood flow and detoxicating treatment for patients with recurrent UC can more effectively decrease the levelof colon tissue P-glucoprotein than treatment with Salazosulfapyridine.At the same time, the drug-resistance is restrained, and this canraise the curative effect and decrease the recurrence of the disease. |
|
|
|
|
|
|
|
