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| Effect of Lingqi-capsule on gene expression of p53 and bcl-2 on sarcoma S180-bearing mice |
| Hits 2377 Download times 1793 Received:June 11, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2009.01.25 |
| Key Words
Lingqi-capsule;Antitumor;Mutant;gene p53;gene bcl-2 |
| Author Name | Affiliation | | SU Yun-ming | Heilongjiang University of TCM, Ha’erbin 150040, China | | MENG Yan | Heilongjiang University of TCM, Ha’erbin 150040, China | | LI Hui | Heilongjiang University of TCM, Ha’erbin 150040, China | | 张学会 | Heilongjiang University of TCM, Ha’erbin 150040, China | | 李环 | Heilongjiang University of TCM, Ha’erbin 150040, China |
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| Abstract
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| [Objective] To discuss the antitumor effect of Lingqi-capsule on sarcoma S180-bearing mice.[Methods] In vivo experiment wasAdopted and ascites sample from sarcoma S180-bearing mice grew for 7 days in asepsis condition.The sample was diluted for 1:3 withasepsis brine (about included sarcoma cell 2×109/mL), inoculated into skin of right forelegs with 0.2ml per mice for establishing themodel of sarcoma S180-bearing mice.After giving Lingqi-capsule for 11 days the immunity organs index and the gene expression of p53 and bcl-2 in each group were compared with the model group.[Results] Lingqi-capsule could obviously inhibit tumor growing withoutlosing of body weight and influencing immune organs.The gene expression of p53 and bcl-2 in each group was less than that of the modelgroup.[Conclusion] Lingqi-capsule can obviously inhibit sarcoma S180 mice growing.The mechanism of action may be correlated withdecreasing of p53 and bcl-2 gene expression.The aim of this thesis was looking for a new medicine having effect both raising immunityand antitumor from Chinese herbal medicine.Lingqi-capsule was proved to be a promising medicine by this experiment. |
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