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| Study on effect of Xianzhong injection on histomorphology of knee and interleukin-1β、prostaglandin E2 in rabbits with early stage osteoarthritis |
| Hits 2076 Download times 2110 Received:October 11, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2009.01.32 |
| Key Words
Knee osteoartritis;Xianzhong Injection;Histomorphology;Interleukin-1β;Prostaglandin E2 |
| Author Name | Affiliation | | WANG Yu-qiang | Department of Orthopedics, Affiliated Hospital of Medical College of Chinese People’s Armed Police Force, Tianjin 300162, China | | WANG Xiao-hua | Department of Orthopedics, Affiliated Hospital of Medical College of Chinese People’s Armed Police Force, Tianjin 300162, China | | YANG Fu-guo | The Hospital Affiliated to Shanxi University of Chinese Medicine, Xianyang 712083, China | | 曹飞 | The Hospital Affiliated to Shanxi University of Chinese Medicine, Xianyang 712083, China |
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| Abstract
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| [Objective] To investigate the Effect of Xianzhong (XI) Injection on Histomorphology of Knee and Interleukin-1β (IL-1β) 、Prostaglandin E2 (PGE2) in Rabbits with Early Stage Osteoarthritis (OA).[Mothods] One Handred and twenty rabbits were randomly divided into 5 groups,the blank group,the model group treated with 0.5ml normal saline once a week,the positive control group treated with 0.5ml hyaluronate once a week,and the XI 1 group and XI 2 group with 0.5ml XI once and twice a week,respectively,all the medicineswere medicated via intra-articular injection.The Patholoyical charge of histomorghology of cartilage and synovial were observed by Mallo-ry staining 8 weeks after modeling, and Interleukin-1β and Prostaglandin E2 content in synovia were detected as well.[Result] Histomor-phology examination showed there was no calcifiction in all the layers of cartilage in the positive control group and the XI 1 group with complete cartiaginuous bluish-green collagen preserved.The Makin grading Indicating the effection that in the XI 1 group was equivalent to that in the positve control group (P>0.05),and that were better in the two XI groups and the positive control group than that in the modelgroup (P<0.05).The content of Interleuk in-1β and Prostagl and in E2 decreased in synovia in the postive control group and the two XI groupas compared with that in the model group (P>0.05).[Conclusion] XI can repair the degenerative cartilage in early OA. |
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