|
| Study on the pharmacological actions of gradated dose of defatted croton seed powder |
| Hits 2187 Download times 2247 Received:September 12, 2008 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2009.01.33 |
| Key Words
defatted croton seed powder;Diarrhea;Intestinal absorption;Intestinal movement |
| Author Name | Affiliation | | WANG Xin | Tianjin Medical University, Tianjin 300070, China | | WANG Hong | Tianjin Medical University, Tianjin 300070, China | | LI Dan | Tianjin Medical University, Tianjin 300070, China | | 唐方 | 天津医科大学总医院 天津 300052 |
|
| Abstract
|
| [Objective] To explore the pharmacological actions of gradated dose of defatted croton seed powder.[Methods] Gradated doseof defatted crotons seed powder was used locally in the rabbit ileum.The Rabbits were divided into five groups:the first group used defatted croton of 2.22×10-2g/L, the second group 4.44×10-2 g/L, the third 6.66×10-2 g/L, the fourth group 4.45×10-1 g/L, the control groupused 0.9%NaCl.Two hours later the remained amount of liquid metabolism was compared.Using Cassia angustifolia diarrhea was in-duced in rats.These rats were allocated to four groups:normal group, model group, first group of defatted croton at concentration of 8.33×10-4 mg/ml, second group of croton of concentration 1.67×10-3 g/L.The incidence of loose stools, serum D-xylose content, the propulsiverate of Carbo Medicinalis in colon of each group were also detected.[Results] The remained liquid of the croton in the first group and thesecond group was lower than that of the control group (P<0.01), the remained liquid had no significant difference between the three crotongroups and the control group (P>0.05), the remained liquid remained of croton in the fourth group was higher than that of the control group (P<0.01).Compared with the control group, the loose stools incidence (P<0.01) and Carbo Medicinalis prppulsive rate (P<0.05) were increased and the serum D-xylose content (P<0.05) was decreased in the model group.Compared with the model group, the loose stools rateand Carbo Medicinalis propulsive rate were decreased (P<0.05) and the serum D-xylose content was increased (P<0.05) in the defattedcroton in the first and second group.[Conclusion] The defatted croton seed powder may significantly increase liquid exudation of ileum,but with reducing of the dose, this action was reversed.Small dose of the croton can promote the liquid absorption of ileum.The 1/20-1/10 of the common dose of the croton can decrease the loose stools rate of diarrhea rats.This effect may be associated with the increasing ofthe liquid absorption of ileum, decreasing of the pathological intestinal squirm and improving intestinal absorption. |
|
|
|
|
|
|
|
