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| Modification of animal model of duodenum gastroesophageal reflux |
| Hits 1348 Download times 1768 Received:September 16, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2009.02.23 |
| Key Words
esophagitis;duodenal gastroesophageal reflux;model;rat |
| Author Name | Affiliation | | CAO Li-xia | Tianjin University of TCM, Tianjin 300193, China | | YUAN Hong-xia | 天津中医药大学, 天津, 300193 | | YANG You-xin | 天津中医药大学, 天津, 300193 | | 代二庆 | 武警医学院附属医院, 天津, 300162 | | 赵强 | 天津中医药大学第一附属医院, 天津, 300193 |
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| Abstract
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| [Objective] To improve the "Esophagus duodenum end-to-side anastomosis technology" and perfect the animal model of Duodenal gastroesophageal reflux. [Methods] In Model group (A) the "Four walls four pins" of the author was adopted while in the control group (B) the end-to side esophagus duodenum anastomosis modified was adopted. [Results] There was no difference in pH values of mucous membrane at the lower esophageal segment between the two groups (P>0.05). The survival rate of rats in model (85%) and the control group (65% ) was significantly different (P<0.05). There was significant difference between the two groups on the performance of esophageal mucosa(P<0.05),but no difference on pathological changes(P>0.05). [Conclusion] The improved model can successfully induce the reflux esophagitis and Barrett’s esophagus on the basis of increasing in survival rate. |
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